High levels of thyroid hormones promote recurrence of Graves' disease via overexpression of B-cell-activating factor.

ABSTRACT:

Background

Elevated thyroid hormone (TH) levels have been suggested to be associated with the pathological progression of Graves' disease (GD). However, direct evidence from clinical studies remains unclear.

Methods

Peripheral blood samples were collected from patients with or without the recurrence of Graves' hyperthyroidism (GH) and healthy donors. Thyroid tissue samples were obtained from patients with benign thyroid nodules. To assess the differentiation of autoreactive B cells, the expression of B-cell-activating factor (BAFF) and the proportion of CD11c+/-IgG+/- subsets of B cells stimulated by high levels of triiodothyronine (T3) in vivo and in vitro were examined by ELISA, flow cytometry, western blotting, and qRT-PCR.

Results

Serum BAFF levels in patients wit

SUBMITTER: Liu S 

PROVIDER: S-EPMC9550970 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature