Folate receptor-positive circulating tumor cells in the preoperative diagnosis of indeterminate pulmonary nodules.

ABSTRACT:

Background

The use of FR + CTC to distinguish lung cancer from benign lung disease has been well studied. However, the effective method to differentiate precursor glandular lesions from benign/malignant pulmonary diseases is rare.

Methods

380 patients with indeterminate pulmonary nodules were prospectively recruited. Peripheral blood samples were collected from all participants before surgery for analyzing FR + CTC levels. The performance of FR + CTC to identify lung precursor lesions were analyzed by receiver operating characteristic (ROC) curve.

Results

FR + CTC can effectively differentiate precursor from benign pulmonary diseases in all included patients (cutoff: 9.22 FU/3 ml, AUC = 0.807, (p < 0.0001, sensitivity: 69.17%, specificity: 82.46%) and patients with si

SUBMITTER: Li Z 

PROVIDER: S-EPMC9550973 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature