Correlation between platelet-derived growth factor-B gene polymorphism and coronary heart disease.

ABSTRACT:

Object

The aim of the present work was to investigate the correlation of plasma platelet-derived growth factor (PDGF)-BB level and single nucleotide polymorphism (SNP, rs1800817 and rs2285094) of PDGF-B gene with the onset and stability condition of coronary heart disease (CHD).

Methods

Totally, 335 subjects were included in and divided into CHD (n = 247) and control group (n = 88) according to coronary angiography. Besides, the patients in the CHD group were divided into acute coronary syndrome (ACS) group (n = 165) and stable angina pectoria (SAP) group (n = 82), based on CHD stability condition. The plasma PDGF-BB level was measured by ELISA, and the genotype of PDGF-B was examined through qPCR assay.

Results

The PDGF-BB level was positively correlated with hsCRP l

SUBMITTER: Lu Y 

PROVIDER: S-EPMC9550974 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature