Alternative pacing strategies for optimal cardiac resynchronization therapy.

ABSTRACT: Cardiac resynchronization therapy (CRT) via biventricular pacing (BVP) improves morbidity, mortality, and quality of life, especially in subsets of patients with impaired cardiac function and wide QRS. However, the rate of unsuccessful or complicated left ventricular (LV) lead placement through coronary sinus is 5-7%, and the rate of "CRT non-response" is approximately 30%. These reasons have pushed physicians and engineers to collaborate to overcome the challenges of LV lead implantation. Thus, various alternatives to BVP have been proposed to improve CRT effectiveness. His bundle pacing (HBP) has been increasingly used by activating the His-Purkinje system but is constrained by challenging implantation, low success rates, high and often unstable thresholds, and low perception. The

SUBMITTER: Hua J 

PROVIDER: S-EPMC9551024 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature