Disruption of adipocyte YAP improves glucose homeostasis in mice and decreases adipose tissue fibrosis.

ABSTRACT:

Objective

Adipose tissue is a very dynamic metabolic organ that plays an essential role in regulating whole-body glucose homeostasis. Dysfunctional adipose tissue hypertrophy with obesity is associated with fibrosis and type 2 diabetes. Yes-associated protein 1 (YAP) is a transcription cofactor important in the Hippo signaling pathway. However, the role of YAP in adipose tissue and glucose homeostasis is unknown.

Methods

To study the role of YAP with metabolic stress, we assessed how increased weight and insulin resistance impact YAP in humans and mouse models. To further investigate the in vivo role of YAP specifically in adipose tissue and glucose homeostasis, we developed adipose tissue-specific YAP knockout mice and placed them on either chow or high fat diet (HFD) for 1

SUBMITTER: Han DJ 

PROVIDER: S-EPMC9551211 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature