Vaccine effectiveness of primary series and booster doses against covid-19 associated hospital admissions in the United States: living test negative design study.

ABSTRACT:

Objective

To compare the effectiveness of a primary covid-19 vaccine series plus booster doses with a primary series alone for the prevention of hospital admission with omicron related covid-19 in the United States.

Design

Multicenter observational case-control study with a test negative design.

Setting

Hospitals in 18 US states.

Participants

4760 adults admitted to one of 21 hospitals with acute respiratory symptoms between 26 December 2021 and 30 June 2022, a period when the omicron variant was dominant. Participants included 2385 (50.1%) patients with laboratory confirmed covid-19 (cases) and 2375 (49.9%) patients who tested negative for SARS-CoV-2 (controls).

Main outcome measures

The main outcome was vaccine effectiveness against hospital admission

SUBMITTER: Adams K 

PROVIDER: S-EPMC9551237 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature