Dysregulation and therapeutic targeting of RNA splicing in cancer.

ABSTRACT: High-throughput sequencing and functional characterization of the cancer transcriptome have uncovered cancer-specific dysregulation of RNA splicing across a variety of cancers. Alterations in the cancer genome and dysregulation of RNA splicing factors lead to missplicing, splicing alteration-dependent gene expression and, in some cases, generation of novel splicing-derived proteins. Here, we review recent advances in our understanding of aberrant splicing in cancer pathogenesis and present strategies to harness cancer-specific aberrant splicing for therapeutic intent.

SUBMITTER: Stanley RF 

PROVIDER: S-EPMC9551392 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature