Pediatric percentiles for transient elastography measurements - effects of age, sex, weight status and pubertal stage.

ABSTRACT:

Background and aims

Transient Elastography is a non-invasive, cost-efficient, non-ionizing, observer-independent and reliable method to detect liver fibrosis using Liver Stiffness Measurement (LSM) and the degree of fat accumulation in the liver using Controlled Attenuation Parameter (CAP). This study aims to derive reference values for both measures from healthy children and adolescents. Further, we aim to assess the potential influence of age, sex, puberty, and BMI-SDS on CAP and LSM.

Methods

Within the LIFE Child study, amongst others, anthropometric data and pubertal status were assessed. Transient Elastography (TE) was performed using the FibroScan^® device in a population-based cohort at 982 study visits of 482 healthy children aged between 10 and 18 years. P

SUBMITTER: Brunnert L 

PROVIDER: S-EPMC9551398 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature