Is immunotherapy at reduced dose and radiotherapy for older patients with locally advanced non-small lung cancer feasible?—a narrative review by the international geriatric radiotherapy group

ABSTRACT:

Background and Objective

The standard of care for locally advanced non-small cell lung cancer (NSCLC) is either surgery followed by adjuvant chemotherapy with or without radiotherapy or concurrent chemotherapy and radiotherapy. However, older patients (70 years old or above) with multiple co-morbidities may not be able to tolerate the combined treatment due to its toxicity. Since lung cancer prevalence increases significantly with age, a new algorithm needs to be investigated to allow curative treatment for those with locally advanced disease.

Methods

A literature search of the literature was conducted through PubMed and Google Scholar using search terms such as locally advanced NSCLC, older cancer patients, immunotherapy with check point inhibitors (CPI), and image-guide

SUBMITTER: Vinh-Hung V 

PROVIDER: S-EPMC9552052 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature