High expression of ceramide synthase 5 predicts a poor prognosis in gastric cancer.

ABSTRACT:

Background

Gastric cancer is one of the most common malignant tumors worldwide. Ceramide synthase 5 (CerS5) is a member of the CerS family. Emerging evidence has shown that overexpressed CerS5 is correlated with the poor prognosis of cancer patients. However, the role of CerS5 in gastric cancer remains unclear. The aim of this study is to delineate the relevance of CerS5 levels to gastric cancer.

Methods

The expression level of CerS5 was determined by immunohistochemistry, and the survival data of gastric cancer patients were obtained by regular follow-up. The gene expression profile of CerS5 and corresponding clinical features of gastric cancer patients from public databases were obtained from The Cancer Genome Atlas (TCGA) and Asian Cancer Research Group (ACRG). The

SUBMITTER: Zhang S 

PROVIDER: S-EPMC9552061 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature