A newly identified pyroptosis-related gene signature for predicting prognosis of patients with hepatocellular cancer

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a very heterogeneous illness, making prognosis prediction a huge problem. Pyroptosis, which has recently been shown to be an inflammatory type of programmed cell death, is involved in HCC. Nevertheless, the role of pyroptosis-related genes in HCC has not been fully elucidated. Thus, this study aimed to construct a prognostic signature based on pyroptosis-related genes for HCC.

Methods

The messenger RNA expression patterns of HCC patients, as well as the accompanying clinical information, were retrieved from The Cancer Genome Atlas (TCGA) database for this research. After differentially expressed pyroptosis-related Gene in tumor and normal groups were identified, Cox regression analyses were performed to construct a prognostic s

SUBMITTER: Shen Q 

PROVIDER: S-EPMC9552084 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature