A comprehensive pan-cancer analysis on the immunological role and prognostic value of TYMP in human cancers

ABSTRACT:

Background

The TYMP gene encodes an important nucleoside metabolism enzyme which is a rate-limiting enzyme for chemotherapeutic drug metabolism. Previous studies have shown that TYMP is highly expressed in many different tumors, promoting invasiveness and progression, and that it helps to predict the response to chemotherapeutic drugs. However, the role of TYMP in tumor immunity and prognosis remains largely unclear. The purpose of this pan-cancer analysis was to acquire more data on the function of TYMP function and its clinical significance.

Methods

To access the TYMP expression, we accessed datasets from The Cancer Genome Atlas (TCGA), Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), Cancer Cell Line Encyclopedia (CCLE) databases, and analyzed its diff

SUBMITTER:  

PROVIDER: S-EPMC9552085 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature