Defining the Patchy Landscape of Esophageal Eosinophilia in Children With Eosinophilic Esophagitis.

ABSTRACT:

Background & aims

Eosinophilic esophagitis (EoE) is a patchy disease of the esophagus with significant variability in intraepithelial eosinophilia. Three biopsies each from distal and proximal esophagus are recommended for identification of active EoE. Recent work suggests 3 biopsy sites are more optimal. We sought to evaluate 2-site vs 3-site esophageal biopsy combinations for utility to identify active EoE.

Methods

We prospectively obtained 3-site esophageal biopsies based on rigorous endoscopic measurements of the proximal, mid, and distal esophagus and gastroesophageal junction. Biopsies were reviewed by a pathologist, and those with at least 15 eosinophils per high-power field were considered active EoE. The sensitivity of one or more sites to identify active EoE was de

SUBMITTER: Wechsler JB 

PROVIDER: S-EPMC9552248 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature