Refractory eosinophilic esophagitis: what to do when the patient has not responded to proton pump inhibitors, steroids and diet.

ABSTRACT:

Purpose of review

Management for patients with refractory eosinophilic esophagitis (EoE) remains a clinical challenge. This review aims to define refractory EoE, explore rates and reasons for nonresponse, and discuss the evidence that informs the approach to these patients.

Recent findings

Many patients will fail first-line therapies for EoE. Longer duration of therapy can increase response rates, and initial nonresponders may respond to alternative first-line therapies. There are ongoing clinical trials evaluating novel therapeutics that hold promise for the future of EoE management. Increasingly, there is recognition of the contribution of oesophageal hypervigilance, symptom-specific anxiety, abnormal motility and oesophageal remodelling to ongoing clinical symptoms in pat

SUBMITTER: Strauss AL 

PROVIDER: S-EPMC9552275 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature