Genomic analysis of the endosomal sorting required for transport complex III pathway genes as therapeutic and prognostic biomarkers for endometrial carcinoma.

ABSTRACT:

Background

The genes involved in the endosomal sorting required for transport complex (ESCRT)-III pathway is a protective mechanism that delays cell death by repairing damaged plasma membranes. We aimed to evaluate if targeting ESCRT-III genes may be used as biomarkers for predicting the clinical outcomes of endometrial carcinoma (EC).

Methods

Transcriptome RNA sequence (RNA-seq) data and genomic information of EC samples were obtained from The Cancer Genome Atlas (TCGA). The expression level, pathological relationship, pathway alterations, mutation, functional enrichment, associations with tumor infiltrating lymphocytes (TILs), and survival information of ESCRT-III genes including charged multivesicular body protein 2A (CHMP2A), CHMP2B, CHMP3<

SUBMITTER: Yang Y 

PROVIDER: S-EPMC9552276 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature