Efficacy and safety of methylene blue in patients with vasodilatory shock: A systematic review and meta-analysis

ABSTRACT:

Background

The role of methylene blue (MB) in patients with vasodilatory shock is unclear. The purpose of this systematic review and meta-analysis was to evaluate the efficacy and safety of MB in patients with vasodilatory shock.

Methods

We searched MEDLINE at PubMed, Embase, Web of Science, Cochrane, CNKI, CBM and Wanfang Medical databases for all observational and intervention studies comparing the effect of MB vs. control in vasodilatory shock patients. This study was performed in accordance with the PRISMA statement. There were no language restrictions for inclusion.

Results

A total of 15 studies with 832 patients were included. Pooled data demonstrated that administration of MB along with vasopressors significantly reduced mortality [odds ratio (OR) 0.54, 95

SUBMITTER: Zhao C 

PROVIDER: S-EPMC9552293 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature