Incidence of in Situ vs Invasive Melanoma: Testing the "Obligate Precursor" Hypothesis.

ABSTRACT:

Background

Melanoma incidence has been rising in populations with predominantly European ancestry (White), speculated to be partly driven by heightened detection of indolent tumors. If in situ melanomas are destined to evolve to invasive cancers, detecting and removing them should deplete the pool of invasive lesions, and people with in situ melanoma should, on average, be younger than those with invasive melanoma.

Methods

We analyzed long-term incidence trends (1982-2018) for in situ and invasive melanomas in 3 predominantly White populations with high, medium, and low melanoma rates: Queensland (Australia), United States White, and Scotland. We calculated the incidence rate ratio (IRR) of in situ to invasive melanomas and estimated the contributions of age, period, and coh

SUBMITTER: Olsen CM 

PROVIDER: S-EPMC9552301 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature