Refractory Helicobacter pylori infection and the gastric microbiota.

ABSTRACT:

Background

Curing refractory Helicobacter pylori infection is difficult. In addition, there is currently no research on the gastric microbiota of refractory H. pylori infection.

Methods

We designed a clinical retrospective study involving 32 subjects divided into three groups: 1. nAGHp.a, treatment-naïve patients with H. pylori infection; 2. nAGHp.b, H. pylori-negative patients; and 3. EFHp.a, patients with refractory H. pylori infection. Gastric mucosal samples from the biobank of our research center were collected for 16S rRNA sequencing analysis and bacterial functions were predicted via PICRUSt.

Results

There were significant differences between the H. pylori- positive group and the H. pylori-negative group i

SUBMITTER: Liu D 

PROVIDER: S-EPMC9552320 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature