Association between CYP2D6 phenotype and recurrence of Plasmodium vivax infection in south Korean patients.

ABSTRACT:

Background

Primaquine is activated by CYP2D6 in the hepatocytes. In Korea, primaquine is the only hypnozoitocidal agent used for patients with vivax malaria. Thus, patients with poor CYP2D6 activity could have an increased risk of primaquine failure and subsequent relapse. The study sought to identify the association between CYP2D6 phenotype and recurrence of malaria in Korean patients.

Methods

A total of 102 patients with vivax malaria were prospectively enrolled from eight institutions in Korea. An additional 38 blood samples from patients with recurred vivax malaria were provided by the Korea Disease Control and Prevention Agency. Malaria recurrence was defined as more than one episode of vivax malaria in the same or consecutive years. CYP2D6 star alleles, phenotypes, and

SUBMITTER: Choi S 

PROVIDER: S-EPMC9552356 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature