High platelet-to-lymphocyte ratios in triple-negative breast cancer associates with immunosuppressive status of TILs.

ABSTRACT:

Background

Rating lymphocytes (TILs) are a prognostic marker in breast cancer and high TIL infiltration correlates with better patient outcomes. Meanwhile, parameters involving immune cells in peripheral blood have also been established as prognostic markers. High platelet-to-lymphocyte ratios (PLRs) and neutrophil-to-lymphocyte ratios (NLRs) are related to poor outcomes in breast cancer, but their mechanisms remain unknown. To date, TILs and these parameters have been examined separately.

Methods

We investigated the relationship between TILs and the peripheral blood markers, PLR and NLR, in the same patients, using surgical specimens from 502 patients with invasive breast carcinoma without preoperative chemotherapy. For analysis of triple-negative breast cancer (TNBC) patie

SUBMITTER: Onagi H 

PROVIDER: S-EPMC9552414 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature