Contact osteogenesis by biodegradable 3D-printed poly(lactide-co-trimethylene carbonate).

ABSTRACT:

Background

To support bone regeneration, 3D-printed templates function as temporary guides. The preferred materials are synthetic polymers, due to their ease of processing and biological inertness. Poly(lactide-co-trimethylene carbonate) (PLATMC) has good biological compatibility and currently used in soft tissue regeneration. The aim of this study was to evaluate the osteoconductivity of 3D-printed PLATMC templates for bone tissue engineering, in comparison with the widely used 3D-printed polycaprolactone (PCL) templates.

Methods

The printability and physical properties of 3D-printed templates were assessed, including wettability, tensile properties and the degradation profile. Human bone marrow-derived mesenchymal stem cells (hBMSCs) were used to evaluate osteoconductivity

SUBMITTER: Hassan MN 

PROVIDER: S-EPMC9552430 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature