Fetal exposure to phthalates and bisphenols and DNA methylation at birth: the Generation R Study.

ABSTRACT:

Background

Phthalates and bisphenols are non-persistent endocrine disrupting chemicals that are ubiquitously present in our environment and may have long-lasting health effects following fetal exposure. A potential mechanism underlying these exposure-outcome relationships is differential DNA methylation. Our objective was to examine the associations of maternal phthalate and bisphenol concentrations during pregnancy with DNA methylation in cord blood using a chemical mixtures approach.

Methods

This study was embedded in a prospective birth cohort study in the Netherlands and included 306 participants. We measured urine phthalates and bisphenols concentrations in the first, second and third trimester. Cord blood DNA methylation in their children was processed using the Illumi

SUBMITTER: Sol CM 

PROVIDER: S-EPMC9552446 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature