Cervical muscle stiffness and parasympathetic nervous system improvements for treatment-resistant depression.

ABSTRACT:

Background

Although treatment-resistant depression (TRD) is a major public health problem that increases mortality due to suicides, a considerable percentage of patients do not respond adequately to variable treatments. Patients with TRD sometimes have comorbid cervical stiffness. This observational study aims to examine the association of local modulation of cervical muscles with TRD and to learn the involvement of the parasympathetic nervous system in the underlying mechanism.

Methods

A total of 1103 hospitalized patients with TRD who were resistant to outpatient care were enrolled between May 2006 and October 2021. All patients underwent local modulation of the cervical muscles by physical therapy during hospitalization. The presence or absence of TRD and whole-body disor

SUBMITTER: Matsui T 

PROVIDER: S-EPMC9552456 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature