Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study.

ABSTRACT:

Background

Gout is a highly hereditary disease, but not all those carrying well-known risk variants have developing gout attack even in hyperuricemia status. We performed a genome-wide association study (GWAS) and polygenic risk score (PRS) analysis to illustrate the new genetic architectures of gout and asymptomatic hyperuricemia (AH).

Methods

GWAS was performed to identify variants associated with gout/AH compared with normouricemia. The participants were males, enrolled from the Taiwan Biobank and China Medical University, and divided into discovery (n=39,594) and replication (n=891) cohorts for GWAS. For PRS analysis, the discovery cohort was grouped as base (n=21,814) and target (n=17,780) cohorts, and the score was estimated by grouping the polymorphisms into protectiv

SUBMITTER: Chang YS 

PROVIDER: S-EPMC9552457 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature