One-step fabrication of lidocaine/CalliSpheres^® composites for painless transcatheter arterial embolization.

ABSTRACT:

Background

Transcatheter arterial embolization (TAE) is one of the first-line treatments for advanced hepatocellular cancer. The pain caused by TAE is a stark complication, which remains to be prevented by biomedical engineering methods.

Methods

Herein, a commercial embolic agent CalliSpheres^® bead (CB) was functionally modified with lidocaine (Lid) using an electrostatic self-assembly technique. The products were coded as CB/Lid-n (n = 0, 5, 10, corresponding to the relative content of Lid). The chemical compositions, morphology, drug-loading, and drug-releasing ability of CB/Lid-n were comprehensively investigated. The biocompatibility was determined by hemolysis assay, live/dead cell staining assay, CCK8 assay, immunofluorescence (IHC) staining assay and quanti

SUBMITTER: Tian C 

PROVIDER: S-EPMC9552470 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature