Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary gland.

ABSTRACT:

Background

The pituitary gland regulates essential physiological processes such as growth, pubertal onset, stress response, metabolism, reproduction, and lactation. While sex biases in these functions and hormone production have been described, the underlying identity, temporal deployment, and cell-type specificity of sex-biased pituitary gene regulatory networks are not fully understood.

Methods

To capture sex differences in pituitary gene regulation dynamics during postnatal development, we performed 3' untranslated region sequencing and small RNA sequencing to ascertain gene and microRNA expression, respectively, across five postnatal ages (postnatal days 12, 22, 27, 32, 37) that span the pubertal transition in female and male C57BL/6J mouse pituitaries (n = 5-6 biologica

SUBMITTER: Hou H 

PROVIDER: S-EPMC9552479 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature