Association between gout and the development of Parkinson's disease: a systematic review and meta-analysis.

ABSTRACT:

Background

As a natural antioxidant, uric acid plays a protective role against neurodegenerative disorders, including Parkinson's disease (PD). Therefore, the risk of PD has been found to be lower in people with hyperuricemia. In this article, we conducted a systematic review and meta-analysis to investigate whether gout affects the future risk of developing PD.

Methods

We searched PubMed, Scopus, the Web of Science, and Google Scholar to find relevant studies, up to March 16, 2022. Studies investigating the risk of PD, following a gout diagnosis, were included if they were cross-sectional, case-control or cohort studies. The Newcastle Ottawa Scale (NOS) checklist was used to assess the quality of all included studies. The meta-analysis was performed using STATA 17.0.

Res

SUBMITTER: Fazlollahi A 

PROVIDER: S-EPMC9552480 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature