Empirical evidence of study design biases in nutrition randomised controlled trials: a meta-epidemiological study.

ABSTRACT:

Background

Instruments to critically appraise randomised controlled trials (RCTs) are based on evidence from meta-epidemiological studies. We aim to conduct a meta-epidemiological study on the average bias associated with reported methodological trial characteristics such as random sequence generation, allocation concealment, blinding, incomplete outcome data, selective reporting, and compliance of RCTs in nutrition research.

Methods

We searched the Cochrane Database of Systematic Reviews, for systematic reviews of RCTs, published between 01 January 2010 and 31 December 2019. We combined the estimates of the average bias (e.g. ratio of risk ratios [RRR] or differences in standardised mean differences) in meta-analyses using the random-effects model. Subgroup analyses were co

SUBMITTER: Stadelmaier J 

PROVIDER: S-EPMC9552513 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature