Evolutionary analyses of genes in Echinodermata offer insights towards the origin of metazoan phyla.

ABSTRACT: Despite recent studies discussing the evolutionary impacts of gene duplications and losses among metazoans, the genomic basis for the evolution of phyla remains enigmatic. Here, we employ phylogenomic approaches to search for orthologous genes without known functions among echinoderms, and subsequently use them to guide the identification of their homologs across other metazoans. Our final set of 14 genes was obtained via a suite of homology prediction tools, gene expression data, gene ontology, and generating the Strongylocentrotus purpuratus phylome. The gene set was subjected to selection pressure analyses, which indicated that they are highly conserved and under negative selection. Their presence across broad taxonomic depths suggests that genes required to form a phylum are ancestral

SUBMITTER: Foley S 

PROVIDER: S-EPMC9552553 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature