Genome-wide association study in patients with posterior urethral valves.

ABSTRACT: Congenital lower urinary tract obstructions (LUTO) are most often caused by posterior urethral valves (PUV), a male limited anatomical obstruction of the urethra affecting 1 in 4,000 male live births. Little is known about the genetic background of PUV. Here, we report the largest genome-wide association study (GWAS) for PUV in 4 cohorts of patients and controls. The final meta-analysis included 756 patients and 4,823 ethnicity matched controls and comprised 5,754,208 variants that were genotyped or imputed and passed quality control in all 4 cohorts. No genome-wide significant locus was identified, but 33 variants showed suggestive significance (P < 1 × 10^-5). When considering only loci with multiple variants residing within < 10 kB of each other showing suggestive signi

SUBMITTER: van der Zanden LFM 

PROVIDER: S-EPMC9552614 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature