Up-Regulated Proteins Have More Protein-Protein Interactions than Down-Regulated Proteins.

ABSTRACT: Microarray technology has been successfully used in many biology studies to solve the protein-protein interaction (PPI) prediction computationally. For normal tissue, the cell regulation process begins with transcription and ends with the translation process. However, when cell regulation activity goes wrong, cancer occurs. Microarray data can precisely give high accuracy expression levels at normal and cancer-affected cells, which can be useful for the identification of disease-related genes. First, the differentially expressed genes (DEGs) are extracted from the cancer microarray dataset in order to identify the genes that are up-regulated and down-regulated during cancer progression in the human body. Then, proteins corresponding to these genes are collected from NCBI, and then the STRI

SUBMITTER: Dey L 

PROVIDER: S-EPMC9552713 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature