Mendelian Randomization Study on Causal Association of Pyroglutamine with COVID-19.

ABSTRACT:

Background

Glutamine family amino acids such as glutamate, pyroglutamate, and glutamine have been shown to play important roles in COVID-19. However, it is still unclear about the role of pyroglutamate in COVID-19. Thus, we use a two-sample Mendelian randomization (MR) study to identify the genetic causal link between blood pyroglutamine levels and COVID-19 risk.

Methods

Pyroglutamine genetic instrumental variables (IVs) were chosen from the largest pyroglutamine-associated genome-wide association studies (GWAS). The largest COVID-19 GWAS dataset was employed to evaluate the causal link between blood pyroglutamine levels and COVID-19 risk using two-sample MR analysis.

Results

We found no significant pleiotropy or heterogeneity of pyroglutamine-associated genetic IVs i

SUBMITTER: Su W 

PROVIDER: S-EPMC9552722 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature