Development and validation of a novel immunotype for prediction of overall survival in patients with clear cell renal cell carcinoma

ABSTRACT:

Background

Clear cell renal cell carcinoma (ccRCC) is a highly immunogenic tumor. The purpose of the present study was to establish a novel immunotype for different immune infiltration and overall survival (OS) of patients with ccRCC.

Methods

Based on the Cancer Genome Atlas Project (TCGA) database (discovery set), a novel immunotype was established using ssGSEA methods. The databases of Fudan University Shanghai Cancer Center (FUSCC) and Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine (XHH) served as an external validation set. GSEA was carried out to identify the immunotype associated signal transduction pathways.

Results

A total of 652 ccRCC patients were included in our study. We constructed a novel immunotype of ccRCC to classif

SUBMITTER: Yu D 

PROVIDER: S-EPMC9552763 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature