Intradermal Testing With COVID-19 mRNA Vaccines Predicts Tolerance.

ABSTRACT:

Background

The newly developed mRNA-based COVID-19 vaccines can provoke anaphylaxis, possibly induced by polyethylene glycol (PEG) contained in the vaccine. The management of persons with a history of PEG allergy or with a suspected allergic reaction after the first dose remains to be defined.

Methods

In this real-life study, we defined two cohorts of individuals: one pre-vaccination including 187 individuals with high-risk profiles for developing anaphylaxis and a second post-vaccination including 87 individuals with suspected allergic reactions after the COVID-19 mRNA vaccine. Upon negative skin test with an mRNA vaccine, a two-step (10-90%) vaccination protocol was performed. Positive skin tests were confirmed with the basophil activation test (BAT).

Results

Among

SUBMITTER: Stehlin F 

PROVIDER: S-EPMC9552867 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature