Blood Leukocyte Counts in Alzheimer Disease.

ABSTRACT:

Importance

Emerging evidence implicates a role for neuroinflammation in Alzheimer disease (AD) pathogenesis, predominantly involving the innate immune system. Blood leukocyte counts are easily accessible markers of immune function; however, their association with the risk of AD is unknown.

Objective

To investigate the observational and genetic associations between types of blood leukocytes and risk of AD.

Design, setting, and participants

In a cohort study comprising observational and genetic analyses, the Copenhagen General Population Study prospective cohort (n = 101 582) was used for the observational analyses. For the genetic studies, nonlinearity was first evaluated for the association between leukocyte cell counts and AD risk using individual-level data from the

SUBMITTER: Luo J 

PROVIDER: S-EPMC9552891 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature