Apoptotic vesicles activate autophagy in recipient cells to induce angiogenesis and dental pulp regeneration.

ABSTRACT: Extracellular vesicles (EVs) derived from living cells play important roles in donor cell-induced recipient tissue regeneration. Although numerous studies have found that cells undergo apoptosis after implantation in an ischemic-hypoxic environment, the roles played by the EVs released by apoptotic cells are largely unknown. In this study, we obtained apoptotic vesicles (apoVs) derived from human deciduous pulp stem cells and explored their effects on the dental pulp regeneration process. Our work showed that apoVs were ingested by endothelial cells (ECs) and elevated the expression of angiogenesis-related genes, leading to pulp revascularization and tissue regeneration. Furthermore, we found that, at the molecular level, apoV-carried mitochondrial Tu translation elongation factor was tran

SUBMITTER: Li Z 

PROVIDER: S-EPMC9552912 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature