Circulating tumor necrosis factor receptors are associated with mortality and disease severity in COVID-19 patients.

ABSTRACT:

Background

Although hyperinflammatory response influences the severity of coronavirus disease 2019 (COVID-19), little has been reported about the utility of tumor necrosis factor (TNF)-related biomarkers in reflecting the prognosis. We examined whether TNF receptors (TNFRs: TNFR1, TNFR2) and progranulin (PGRN) levels, in addition to interleukin 6 (IL-6) and C-reactive protein (CRP), are associated with mortality or disease severity in COVID-19 patients.

Methods

This retrospective study was conducted at Juntendo University Hospital. Eighty hospitalized patients with various severities of COVID-19 were enrolled. Furthermore, serum levels of TNF-related biomarkers were measured using enzyme-linked immunosorbent assay.

Results

Twenty-five patients died during hospitalizat

SUBMITTER: Gohda T 

PROVIDER: S-EPMC9553057 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature