[⁶⁸ Ga]Ga-FAPI-46 PET for non-invasive detection of pulmonary fibrosis disease activity.

ABSTRACT:

Purpose

The lack of effective molecular biomarkers to monitor idiopathic pulmonary fibrosis (IPF) activity or treatment response remains an unmet clinical need. Herein, we determined the utility of fibroblast activation protein inhibitor for positron emission tomography (FAPI PET) imaging in a mouse model of pulmonary fibrosis.

Methods

Pulmonary fibrosis was induced by intratracheal administration of bleomycin (1 U/kg) while intratracheal saline was administered to control mice. Subgroups from each cohort (n = 3-5) underwent dynamic 1 h PET/CT after intravenously injecting FAPI-46 radiolabeled with gallium-68 ([⁶⁸ Ga]Ga-FAPI-46) at 7 days and 14 days following disease induction. Animals were sacrificed following imaging for ex vivo gamma counting and histologic co

SUBMITTER: Rosenkrans ZT 

PROVIDER: S-EPMC9553066 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature