Safety and Efficacy of Vasopressin After Fontan Completion: A Randomized Pilot Study.

ABSTRACT:

Background

Arginine vasopressin is a nonapeptide hormone with effects on intracellular water transport and arterial tone that is used in distributive shock and following cardiopulmonary bypass. We sought to evaluate the safety and efficacy of vasopressin infusion on hemodynamics and fluid balance in the early postoperative period after Fontan completion.

Methods

We conducted a randomized, double-blinded, placebo-controlled study of vasopressin infusion for 24 hours after cardiopulmonary bypass for Fontan completion. Patient characteristics, hospital outcomes, and measures of hemodynamic parameters, urine output, chest tube drainage, fluid balance, laboratory data, and plasma arginine vasopressin concentrations were collected at baseline and for 48 postoperative hours. Data w

SUBMITTER: Bigelow AM 

PROVIDER: S-EPMC9553092 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature