Distribution of ventilation and oxygenation in surgical obese patients ventilated with high versus low positive end-expiratory pressure: A substudy of a randomised controlled trial.

ABSTRACT:

Background

Intra-operative ventilation using low/physiological tidal volume and positive end-expiratory pressure (PEEP) with periodic alveolar recruitment manoeuvres (ARMs) is recommended in obese surgery patients.

Objectives

To investigate the effects of PEEP levels and ARMs on ventilation distribution, oxygenation, haemodynamic parameters and cerebral oximetry.

Design

A substudy of a randomised controlled trial.

Setting

Tertiary medical centre in Geneva, Switzerland, between 2015 and 2018.

Patients

One hundred and sixty-two patients with a BMI at least 35 kg per square metre undergoing elective open or laparoscopic surgery lasting at least 120 min.

Intervention

Patients were randomised to PEEP of 4 cmH 2 O ( n  = 79) or PEEP of 12 cmH 2 O with h

SUBMITTER: Ellenberger C 

PROVIDER: S-EPMC9553219 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature