Role of Uromodulin in Salt-Sensitive Hypertension.

ABSTRACT: The exclusive expression of uromodulin in the kidneys has made it an intriguing protein in kidney and cardiovascular research. Genome-wide association studies discovered variants of uromodulin that are associated with chronic kidney diseases and hypertension. Urinary and circulating uromodulin levels reflect kidney and cardiovascular health as well as overall mortality. More recently, Mendelian randomization studies have shown that genetically driven levels of uromodulin have a causal and adverse effect on kidney function. On a mechanistic level, salt sensitivity is an important factor in the pathophysiology of hypertension, and uromodulin is involved in salt reabsorption via the NKCC2 (Na⁺-K⁺-2Cl^- cotransporter) on epithelial cells of the ascending limb of

SUBMITTER: Mary S 

PROVIDER: S-EPMC9553220 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature