Obesity in children with acute promyelocytic leukemia: What is its prevalence and prognostic significance?

ABSTRACT:

Objective

To compare outcomes of obese and nonobese pediatric patients with acute promyelocytic leukemia (APL) from the Cancer and Leukemia Group B trial (CALGB) 9710 and the Children's Oncology Group trial AAML0631.

Methods

Data including demographics, adverse events, overall and event-free survival (EFS) were analyzed.

Results

The prevalence of obesity was 34% on C9710 and 35% on AAML0631. There was significantly lower overall and EFS in the obese population on multivariable analysis on AAML0631 but not on CALGB 9710. Eleven patients died during therapy or in follow-up.

Conclusion

The prevalence of obesity is higher in pediatric patients with APL compared to the general population. The decreased EFS and OS in obese patients on AAML0631 suggest that the presen

SUBMITTER: Laurie KL 

PROVIDER: S-EPMC9553282 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature