The Effects of Citalopram and Thalamic Dopamine D_2/3 Receptor Availability on Decision-Making and Loss Aversion in Alcohol Dependence.

ABSTRACT: Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed for patients who misuse alcohol, especially in the context of comorbid depressive symptoms. Deficits in impulse control and decision-making are linked to routine alcohol consumption and alcohol dependence. The goal of this study was to determine the effects of a single dose of citalopram on measures of impulsivity, decision-making, and/or brain dopamine receptor availability in alcohol-dependent individuals. A double-blind, placebo-controlled, within-subject, outpatient study was conducted with active alcohol-dependent (DSM-IV-TR criteria) participants (n = 12) and matched healthy controls (n = 13). Serial doses of both citalopram (40 mg) and saline were administered intravenously before laboratory tests

SUBMITTER: Zorick T 

PROVIDER: S-EPMC9553840 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature