A novel high-risk subpopulation identified by CTSL and ZBTB7B in gastric cancer.

ABSTRACT:

Background

Gastric cancer (GC) is characterised by a heterogeneous tumour microenvironment (TME) that is closely associated with the response to treatment, especially immunotherapies. However, most previous GC molecular subtyping systems need complex gene signatures and examination methods, restricting their clinical applications. Thus, we developed a new TME-based molecular subtype using only two genes.

Methods

Nine independent GC cohorts at the tissue- or single-cell level with more than 2000 patients were used in this study, including data we examined by single-cell sequencing, quantitative RT-PCR and immunochemistry/immunofluorescence staining. Nine different methods, five existing molecular subtypes and a series of signatures were used to evaluate the TME and molecular

SUBMITTER: Cui K 

PROVIDER: S-EPMC9553888 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature