A novel circulating miRNA panel for non-invasive ovarian cancer diagnosis and prognosis.

ABSTRACT:

Background

Ovarian cancer (OC) is an aggressive disease, primarily diagnosed in late stages with only 20% of patients surviving more than 5 years after diagnosis. There is a pending need to improve current diagnostics and prognostics.

Methods

In this study, we investigated total circulating cell-free microRNA (cf-miRNA) levels as well as a panel of cf-miRNAs in the plasma of OC patients (n = 100), patients with benign lesions (n = 45) and healthy controls (n = 99).

Results

High levels of cf-miRNAs correlated with unfavourable clinical features and were an independent prognosticator of patient survival. By mining NGS data, we identified a signature panel of seven individual cf-miRNAs which could distinguish controls from benign cases with an AUC of 0.77 and controls fr

SUBMITTER: Gahlawat AW 

PROVIDER: S-EPMC9553930 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature