Immunogenicity and efficacy of COVID-19 vaccines in people living with HIV: a systematic review and meta-analysis.

ABSTRACT:

Objectives

Available data show that COVID-19 vaccines may be less effective in people living with HIV (PLWH) who are at increased risk for severe COVID-19. This meta-analysis aimed to compare the immunogenicity and efficacy of COVID-19 vaccines in PLWH with healthy individuals.

Methods

Pubmed/Medline, EMBASE, and the Cochrane Library were searched. Risk ratios of seroconversion were separately pooled using random-effects meta-analysis, and a systematic review without meta-analysis of SARS-CoV-2 antibody titer levels was performed after the first and second doses of a COVID-19 vaccine.

Results

A total of 22 studies with 6522 subjects met the inclusion criteria. After the first vaccine dose, seroconversion in PLWH was comparable to that in healthy individuals. After a s

SUBMITTER: Yin J 

PROVIDER: S-EPMC9553964 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature