Design of a novel integrated microfluidic chip for continuous separation of circulating tumor cells from peripheral blood cells.

ABSTRACT: Cancer is one of the foremost causes of death globally. Late-stage presentation, inaccessible diagnosis, and treatment are common challenges in developed countries. Detection, enumeration of Circulating Tumor Cells (CTC) as early as possible can reportedly lead to more effective treatment. The isolation of CTC at an early stage is challenging due to the low probability of its presence in peripheral blood. In this study, we propose a novel two-stage, label-free, rapid, and continuous CTC separation device based on hydrodynamic inertial focusing and dielectrophoretic separation. The dominance and differential of wall-induced inertial lift force and Dean drag force inside a curved microfluidic channel results in size-based separation of Red Blood Cells (RBC) and platelets (size between 2-4 µm

SUBMITTER: Bakhshi MS 

PROVIDER: S-EPMC9554048 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature