Circulating HMGB1 is increased in myelodysplastic syndrome but not in other bone marrow failure syndromes: proof-of-concept cross-sectional study.

ABSTRACT:

Background

Myelodysplastic syndrome (MDS) is associated with persistent immune activation. High mobility group box-1 (HMGB1) is a ubiquitous, functionally diverse, non-histone intranuclear protein. During acute and chronic inflammatory states, HMGB1 is actively released by inflammatory cells, further amplifying the inflammatory response. A role in MDS and other hypoplastic bone marrow (BM) disorders is incompletely understood.

Objectives

The objective of the study is to evaluate whether circulating HMGB1 is elevated in patients with MDS and other BM failure syndromes [namely, aplastic anemia (AA) and paroxysmal nocturnal hemoglobinuria (PNH)].

Design

This is a observational, cross-sectional, single-center, exploratory study.

Methods

We evaluated circulating con

SUBMITTER: Apodaca-Chavez E 

PROVIDER: S-EPMC9554121 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature