Deletion of ghrelin alters tryptophan metabolism and exacerbates experimental ulcerative colitis in aged mice.

ABSTRACT: A major component of aging is chronic, low-grade inflammation, attributable in part by impaired gut barrier function. We previously reported that deletion of ghrelin, a peptidergic hormone released mainly from the gut, exacerbates experimental muscle atrophy in aged mice. In addition, ghrelin has been shown to ameliorate colitis in experimental models of inflammatory bowel disease (IBD), although the role of endogenous ghrelin in host-microbe interactions is less clear. Here, we showed that 22-month-old global ghrelin knockout (Ghrl^-/-) mice exhibited significantly increased depressive-like behaviors, while anxiety levels and working memory were similar to littermate wild-type (WT) mice. Furthermore, old Ghrl^-/- mice showed significantly increased intest

SUBMITTER: Tuchaai E 

PROVIDER: S-EPMC9554169 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature