Detailed analysis of in-hospital transmission of SARS-CoV-2 using whole genome sequencing.

ABSTRACT:

Background

Hospital transmission of SARS-CoV-2 has proved difficult to control, with healthcare-associated infections troublesome throughout.

Aim

To understand factors contributing to hospital transmission of infections, which is necessary for containing spread.

Methods

An outbreak of 56 staff and patient cases of COVID-19 over a 31-day period in a tertiary referral unit is presented, with at least a further 29 cases identified outside of the unit and the hospital by whole genome sequencing (WGS).

Findings

Transmission is documented from staff to staff, staff to patients, and patients to staff, showing disruption of a tertiary referral service, despite implementation of nationally recommended control measures, superior ventilation, and use of personal protectiv

SUBMITTER: O'Connell L 

PROVIDER: S-EPMC9554319 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature